A minimum of three regular-season games will be played at Twickenham Stadium over a three-year period from next year, the National Football League have confirmed.
The news comes after the NFL established a new partnership with the RFU, with the first game to be played at Twickenham in 2016 to be announced later this year.
The agreement also gives the NFL the opportunity to stage two additional games over the same period, as well as a step in the right direction for London to eventually have its own franchise.
"We are committed to continuing to grow our sport in the UK and believe that adding Twickenham Stadium to our roster of host venues in London is further evidence of that commitment," said NFL executive vice president of International Mark Waller.
"We are very excited to give our fans the opportunity to enjoy NFL action at another world-class venue famous for attracting loyal and passionate fans from across the globe."
The RFU also welcomed the announcement so soon after hosting a memorable World Cup tournament.
"We are delighted to welcome the NFL to Twickenham, a stadium that has played such an integral role in what has been the biggest Rugby World Cup ever." said Sophie Goldschmidt, the RFU’s chief commercial and marketing officer.
"The NFL has a strong and growing fan base in the UK, and this, combined with the investments we’ve made in our stadium will give fans more opportunities to experience the action first-hand at a world-class venue. We look forward to working with the NFL on this partnership."