The Washington Redskins gave up three years' worth of first-round picks to the St Louis Rams to ensure they were able to secure the Heisman Trophy-winning college superstar out of Baylor, but the team will now move on from Griffin.
After leading the Redskins to the play-offs and an NFC East title in his first season, while securing the offensive rookie of the year award, it has all been downhill.
During the team's wildcard round loss to Seattle, Griffin suffered torn ACL and LCL ligaments in his right knee. A sub-standard 2013 season followed as he was replaced by Kirk Cousins, a fourth-round draft pick, also from the 2012 class.
After a brief 2014 return, he was again deposed by Cousins, who went on to set franchise records for passing yards and touchdowns last season, leading the club back to the play-offs in the process.
In fact, Griffin never took a snap in 2015, falling down to third in the Redskins depth chart behind Colt McCoy.
So, what is next for a quarterback who was once so coveted? Well, it certainly looks like it won't be with Washington.
That's after team president Bruce Allen appeared to confirm that Griffin's future lies elsewhere.
"I see Robert getting an opportunity with another team," said Allen.
"We've heard from some teams that are interested. I think he's going to have a choice of a couple of teams that will let him excel in the future."
So, just where will Griffin land for the 2016 season? We take a look at some of the teams that could offer the 26-year old a second chance in the NFL.
The term 'quarterback-needy' doesn't do the Browns justice. They're desperate for a solution, especially now that it seems the Johnny Manziel experiment is at an end.
The team will get a fresh start in 2016 under new head coach Hue Jackson – a man known for his excellent work with quarterbacks. With Jackson as offensive coordinator last season, Cincinnati Bengals quarterback Andy Dalton had the best passer rating of his career (106.3), also throwing for 25 touchdowns.
Cleveland would seem a good fit for Griffin, but with the franchise up second in this year's draft, they could have the pick of all the quarterbacks available, with many analysts suggesting they could select California's Jared Goff.
Cowboys owner Jerry Jones has never been one to hide his admiration for the aforementioned Manziel, but even he might see it as too much of a risk to take a punt on the controversial quarterback.
Tony Romo is their undisputed starter, but he'll be 36 when the new season starts, and will be coming off the back of an injury-ravaged season that saw him play in only four games. And even with Romo healthy, Dallas need to address their backup situation.
Brandon Weeden, Matt Cassel and Kellen Moore were all tried in Romo's absence, but ultimately, none were successful as the Cowboys slumped to a 4-12 season.
However, there are question marks regarding Griffin's ability to fit in Cowboys coach Jason Garrett's scheme, with some reports suggesting his offensive co-ordinator Scott Linehan simply isn't a fan of the quarterback. But given their lack of depth at the position, Griffin will be considered.
Nobody would be surprised if Griffin ended up in an Eagles uniform next season.
Last season, head coach Chip Kelly traded away Pro Bowl quarterback Nick Foles to the Rams, in exchange for their starter Sam Bradford.
Kelly is now gone, and Bradford failed to match expectations. There's every chance Bradford could re-sign with the Eagles, otherwise he will become a free agent. But Philadelphia and their new coach Doug Pederson will be keeping their options open.
Pederson, a former quarterback himself, helped Alex Smith finally reach his potential in Kansas City while offensive coordinator.
Philadelphia have been searching for a solution at the position since Donovan McNabb's departure in 2009, and Griffin would present a potential long-term option for the franchise.
Bill O'Brien knows how to coach quarterbacks – it's his specialty. The fact the Houston Texans coach led a team that spent a season juggling Brian Hoyer, Ryan Mallett, TJ Yates and Brandon Weeden under center to the play-offs is testament to that.
However, O'Brien tried to make Hoyer his main man, and, in the end, that was the team's downfall. The signal caller's horrendous showing in Houston's 30-0 demolition at the hands of the Kansas City Chiefs made Houston's ever-growing need for a long-term solution at quarterback even more apparent.
Owner Bob McNair has signalled the club's intention to make a change at the position during the off-season, but it could be more likely this will be done via the draft. Christian Hackenberg, who worked under O'Brien at Penn State, could be reunited with his college head coach.
The Texans believe they are just a quarterback away from success, so there's no doubt they will thoroughly exhaust their options. An available Griffin will certainly be in the mix.
They've just won the Super Bowl, but the off-season isn't going to be easy for the Denver Broncos at quarterback.
The legendary Peyton Manning is soon to be 40, and is widely expected to retire.
His back-up Brock Osweiler impressed Denver's front office and coaching staff when he relieved Manning mid-season, and is seen by many as the future of the franchise. But he could be on the way out too.
That's because he's about to become a free agent, and could be tempted by a big-money offer elsewhere. And with Super Bowl MVP Von Miller commanding a huge sum to stay in Denver, the cap room might simply not be there to make Osweiler an offer he can't refuse.
That would leave coach Gary Kubiak with just second-year Trevor Siemian at the position, so it wouldn't be a surprise if they were to turn to Griffin to bulk up their resources.