Jack Eichel scored the game-winning goal to help Buffalo to a 4-2 win over the Columbus Blue Jackets.
The 18-year-old number two draft pick top-shelfed a wrist-shot from the left circle with 9:21 remaining in the third to beat Sergei Bobrovsky and hand the Sabres and new coach Dan Bylsma a first win of the season.
"You're looking at one of the best goalies in the League in Bobrovsky right there," Bylsma said. "We'll see that goal again; we'll see it replayed again, just all of it. It's a pretty remarkable goal."
"I thought we earned the win. I thought we earned it with the way we played. We didn't give them much. They had to battle for every inch. I think we gave them a lot to handle."
Elsewhere, the Flyers gained some semblance of revenge on Florida at Wells Fargo Centre.
Philadelphia were coming off a 7-1 mauling by the Panthers in Sunrise but claimed a 1-0 win on home ice thanks to a Brayden Schenn goal and a 31 saves from goalie Michal Neuvirth, who produced an eighth career NHL shutout.
“We have all the confidence in the world in [Neuvirth]," said Buffalo coach Dave Haksto, who recorded his first NHL win. "He went out tonight and he played a heck of a game."
It was a landmark night for Steven Stamkos too as he recorded his 500th NHL point in just his 495th game as Tampa Bay extended their perfect start to the season with a 6-3 win over Boston.
Stamkos, who admitted it was a “special” night for him, scored the go-ahead goal on the power-play at TD Garden, with Brian Boyle netting twice for Lightning.
Fellow former number one draft pick John Tavares was also in a productive mood, scoring one and adding two assists as New York Islanders beat the Winnipeg Jets 4-2 to win for the first time at Barclays Centre.
Meanwhile, Alexandre Burrows was the Canucks’ shootout hero as Vancouver spoiled the Anaheim Ducks’ home opener with a 2-1 win.