Kansas City Chiefs running back Jamaal Charles will miss the rest of the NFL season with a torn anterior cruciate ligament in his right knee.
Charles was hurt during the Chiefs' 18-17 defeat at home to the Chicago Bears on Sunday and an MRI scan on Monday confirmed the severity of his injury.
This will be the second season of Charles' career that has been ruined, as he missed the final 14 games of the 2011 campaign with a similar injury in his left knee.
Since 2011, the 28-year-old has developed into one of the league's best running backs, scoring 33 total touchdowns in the last two seasons and running for more than 1,000 yards in the last three.
The Chiefs will now turn to Knile Davis and Charcandrick West to lead their running game, and although Davis has a little more experience, it was West who took over against the Bears after Charles hobbled out of the game.
Charles wrote on Twitter: "Big thanks to everyone that has called, text and tweeted me and wished me well. Means the world to me and best believe this is just a minor setback."