Sampdoria took full advantage of Luca Rizzo's second-half sending off to secure a 2-0 victory over Bologna in Monday night's Serie A match in Genoa.
The home side very nearly took the lead on six minutes through Roberto Soriano, who collected
a pass on the edge of the box, but his shot was just wide of the right post.
Bologna came even closer four minutes through a well-taken free kick, but Franco Brienza's
effort rattled off the crossbar.
Those early efforts were not characteristic of what was to come, however, and there was little to trouble either goalkeeper in the remainder of the first half.
Bologna should have taken the lead in extra time through Godfred Donsah, who had only the goalkeeper to beat, but he fired it right into the middle of the goal, where Emiliano Viviano was waiting to pull off the save.
On the hour mark, Eder tried his luck for Sampdoria from long range and his effort was on target, though Antonio Mirante was up to the task in goal.
Two minutes later, Bologna were dealt a serious blow when Luca Rizzo was sent off for a second bookable offence, a moment that would change the entire complexion of the match.
It took a little over 10 minutes for Sampdoria to make their advantage count, as Luis Muriel passed it into the penalty area and found Eder, whose shot went in off the post.
Four minutes later, they had their second, Soriano pulling off a beauty of a strike from just outside the box.
Bologna nearly pulled one back in the final moments of the match, but Brienza's effort was stopped by Viviano as Sampdoria snatched all three points to move into the top half of the table.