Marcus Mariota was the star of the show as the Tennessee Titans beat Tampa Bay Buccaneers 42-12, while St Louis Rams and Buffalo Bills also won on the opening weekend of the NFL.
Here's a breakdown of Sunday's results:
Colts 14-27 Bills
The Buffalo Bills recorded a shock 27-14 win over the Indianapolis Colts to get Rex Ryan's tenure off to the perfect start.
In his first career start, quarter-back Tyrod Taylor completed 14 of 19 passes and threw a 51-yard opening touchdown pass to Percy Harvin, the first of three touchdown drives in the game.
Packers 31-23 Bears
Aaron Rodgers threw three touchdown passes, going 18 of 23 for 189 yards, as the Green Bay Packers beat the Chicago Bears 31-23.
The Bears kept within touching distance of the Packers through the game, but Randall Cobb snatched a five-yard touchdown early in the fourth, before Eddie Lacy scored late on to seal the win.
Chiefs 27-20 Texans
The Houston Texans fourth-quarter fightback proved to be in vain as they went down 27-20 to the Kansas City Chiefs.
Alex Smith threw for 243 yards and three touchdowns as the Chiefs built up their lead, but substitute Texans quarter-back Ryan Mallett made for a nervy finish with two scoring drives late on.
Panthers 20-9 Jaguars
The Jacksonville Jaguars went scoreless in the final two quarters as they succumbed to a 20-9 defeat at the hands of the Carolina Panthers.
Josh Norman intercepted for a 30-yard touchdown in the third-quarter, as the Panthers did just enough offensively to get the win.
Browns 10-31 Jets
Chris Ivory ran in two touchdowns, while Ryan Fitzpatrick threw two more, as the New York Jets beat the Cleveland Browns 31-10.
Johnny Manziel came on late in the first for Cleveland and completed 13 of 24 passes against a solid Jets defensive unit, which had five takeaways against the Browns.
Seahawks 31-34 Rams
It was a close game in St Louis as the Rams claimed a 34-31 win over the defending NFC Champions the Seattle Seahawks in a thrilling overtime encounter.
The Seahawks rallied for 18-points in the fourth quarter, but a Greg Zuerlein field goal from 37-yards out ensured the Rams would claim victory.
Dolphins 17-10 Redskins
Jarvis Landry returned a punt 69 yards in the fourth-quarter, not only giving the Miami Dolphins their first lead of the game, but also helping them to a narrow 17-10 win over the Washington Redskins.
Kirk Cousins threw 21 for 31 and 196 yards for Washington, who led 10-0 in the second quarter. Andrew Franks tied the game with 11:34 remaining with a 22-yard field goal.
Saints 19-31 Cardinals
A strong final quarter that included touchdowns from Darren Fells and David Johnson helped the Arizona Cardinals to a 31-19 win over the New Orleans Saints.
In his first game back from a knee injury, Carson Palmer went 19 of 32 for 307 yards, throwing three touchdown passes for the win.
Lions 28-33 Chargers
The San Diego Chargers maintained their unbeaten record against the Detriot Lions at the Qualcomm Stadium, with final quarter touchdowns from Ladarius Green and Danny Woodhead seeing off an early charge from Detriot as the home side recorded a 33-28 victory.
Bengals 33-13 Raiders
Tyler Eifert and Jeremy Hill each grabbed two touchdowns as the Cincinnati Bengals opened their 2015 NFL campaign with a 33-13 victory over the Oakland Raiders.
Andy Dalton threw for 269 yards, going 25 for 34, as the Bengals opened up a 33-point lead and coasted to the opening-day win.
Titans 42-14 Buccaneers
Rookie quarterback Marcus Mariota made an immediate impact for the Tennessee Titans as he threw four touchdown passes in a 42-14 win over the Tampa Bay Buccaneers.
Fellow rookie quarterback Jameis Winston, number one pick for the Buccaneers in the Draft, had a less than stellar start, having his first NFL throw intercepted and returned for a touchdown.
Ravens 13-19 Broncos
The Denver Broncos edged the Baltimore Ravens 19-13 in a scrappy opening match in which Broncos quarterback Peyton Manning failed to impress.
Manning threw 24 for 40 and went for 175 yards, but failed to throw a single touchdown in the game, while he was also sacked four time, his most since October 2013.
Giants 26-27 Cowboys
The Dallas Cowboys edged the New York Giants after a Jason Witten scored a touchdown with just seven seconds remaining to hand the Tony Romo-led side a 27-26 victory.
The Cowboys had to overcome three turnovers which led to Giants points, Dominique Rodgers-Cromartie returning a fumble 57-yards for a touchdown, while they had to cover just one-yard for their other TD after Trumaine McBride's interception.