Saturday's final Premier League clash sees Manchester United take on Liverpool at Old Trafford in what many regard as the biggest match of the season.
Both sides go into the match on seven points from their first four matches, having lost their most recent matches, against Swansea and West Ham respectively.
Although these two giants of the world game remain England's most successful clubs, both enjoyed poor 2014/15 campaigns and are not favourites to add to their tallies this season.
Nevertheless, this fixture remains the most anticipated on the domestic calendar and as part our build-up to the big match, we take a look at a few of their most memorable clashes at Old Trafford in the Premier League era.
Man United 2-2 Liverpool, 1995
In what was Eric Cantona's first match back from suspension after his suspension for kung-fu kicking a Crystal Palace fan, the Frenchman set up Nicky Butt to open the scoring after just two minutes.
Liverpool striker Robbie Fowler netted twice to put the Reds on the verge of a memorable win over their rivals, before Cantona had the last laugh when he equalised from the penalty spot late on.
Manchester United 1-0 Liverpool, 2006
Although this match wasn't particularly memorable aside from Rio Ferdinand scoring the winner in the last minute of regulation time, this clash will live long in the memory for Gary Neville's celebrations that followed after the final whistle.
Bonus Neville celebration
Manchester United 1 Liverpool 4, 2009
Cristiano Ronaldo gave United the lead from the penalty spot in the first half but that was as good as it got for the Red Devils in this one, as Liverpool dominated the remainder of the match.
Fernando Torres equalised for the Reds following a mistake by Nemaja Vidic, before Steven Gerrard put Rafael Benitez's side ahead – also from the penalty spot.
After the break, Vidic was red-carded and Fabio Aurelio curled home a free-kick from the ensuing free-kick. To add insult to injury, Andrea Dossena lobbed Edwin van der Sar from long range and cap a memorable day for the traveling Reds supporters.
Manchester United 3-2 Liverpool, 2010
Dimitar Berbatov's Man United career may have been something of a disappointment, but the Bulgarian ensured his name was written into the Red Devils annals with this performance.
'Berba' put United ahead just before the half-time interval before doubling their advantage with a stunning overhead kick shortly after the break.
Gerrard once again came to Liverpool's rescue with two goals in six minutes shortly thereafter, before Berbatov completed his hat-trick – the first by a United player against Liverpool since 1946 – with a late header to secure all three points for Sir Alex Ferguson's side.
Manchester United 0 Liverpool 3, 2014
David Moyes' tenure won't be fondly remembered by United fans and this match was perhaps the low-point of his time in charge, as Liverpool dominated from start to finish.
Gerrard opened the scoring from the penalty spot following a Rafael handball, before doubling their advantage with another penalty following a clumsy Phil Jones foul. The Reds skipper missed the third penalty he was awarded on the day when Vidic was sent off for a foul on Daniel Sturridge, but Luis Suarez was at hand to score Liverpool's third soon after.