Wales have called Racing 92 scrum-half Mike Phillips and Ospreys wing Eli Walker into their World Cup squad as injury replacements.
It was confirmed on Tuesday that first-choice scrum-half Rhys Webb has been ruled out of the World Cup because of a foot injury, joining full-back Leigh Halfpenny on the sidelines after the duo were injured in Saturday's final warm-up game against Italy in Cardiff.
Both were part of the initial extended training squad but did not make the final 31-man RWC group.
"It is extremely disappointing for both Leigh and Rhys," said Wales head coach Warren Gatland.
"They have worked exceptionally hard to establish themselves on the world stage and to prepare for the tournament and we wish them all the best with their recovery.
"After announcing the squad we spoke about the need for players to remain ready for action and is a great opportunity for Mike and Eli.
"It's great that we can call on players of this calibre. To bring Mike's experience into the squad is a bonus along with Eli's exciting talent."
Wales say 26-year-old Webb requires further assessments on both his foot and knee before details can be given about whether he requires surgery.