Green Bay Packers wide receiver Jordy Nelson will miss the entire 2015 season due to a right knee injury.
Pro Bowl receiver Nelson, who caught 98 passes for 1,519 yards and 13 touchdowns last season, hurt his knee while making a spinning move after a catch in Sunday's pre-season game against the Pittsburgh Steelers.
"It was determined that WR Jordy Nelson sustained a significant right knee injury in yesterday's game at Pittsburgh. He will miss the remainder of the season," team spokesman Jason Wahlers said in a statement.
The loss of Aaron Rodgers' primary target is a damaging blow for the Packers who were among the favourites for the Super Bowl after being narrowly edged out by the Seahawks in last season's NFC Championship game in Seattle.
Green Bay, however, still have potent targets for the strong-armed Rodgers, who led them to a 12-4 regular season mark in 2014.
Randall Cobb, one of the game's most electrifying pass-catchers, made 91 receptions last season for 1,287 yards and 12 touchdowns.
Now expected to step up are second-year receiver Davante Adams, third-round draft pick Ty Montgomery, along with holdover Jeff Janis and tight ends Andrew Quarless and Richard Rodgers.