In 2014 he finished tied in 16th place and in 2013 he ended tied in 30th place in the two times he has played in the event.
Watson, who is a crowd favourite, also now lives some of the year at the Greenbrier Sporting Club, which could give him a slight advantage over other players.
When asked in an interview about how it would feel to win at his home course, Watson said it would mean a lot to him.
"It would mean a lot, you know, to be a part of the community, a part of West Virginia now," Watson said.
"Anytime you're at your home course it's like you want to protect your home soil. Obviously this would be a big win for me.
"Obviously this week would be even bigger since I just won last week," he added.
The world No. 3 is in great form having won the Travelers Championship last week, making Watson the fourth multiple winner this season on the PGA Tour.
There are a number of strong players that will be taking place in Thursday’s event with Tiger Woods making his second appearance at The Greenbrier.
Other players in the mix are defending champion Angel Cabrera, Paul Casey, Webb Simpson, Louis Oosthuizen, J.B. Holmes and Patrick Reed.
Watson will be paired with Ryder Cup captain Davis Love III and Bill Haas in Thursday's opening round.