With the likes of Roger Federer, Andy Murray and Rafael Nadal in action for the men, all three of them will be looking to take one step closer to winning their first grand slam of the year.
But, there is also a lot on the line in the women's singles event as defending champion Petra Kvitova will face Kurumi Nara in the second round after breezing past Kiki Bertens 6-1, 6-0 in just 36 minutes.
Some of the other high-profile players in the women's draw who will take centre court include world number five Caroline Wozniacki, Ekaterina Makarova and Angelique Kerber, while China's Ying-Ying Duan will be looking to defeat Tatjana Maria after stunning Eugenie Bouchard in the first round.
(2) Roger Federer vs Sam Querrey
(3) Andy Murray vs Robin Haase
(6) Tomas Berdych vs Nicolas Mahut
(10) Rafael Nadal vs Dustin Brown
(2) Petra Kvitova vs Kurumi Nara
(5) Caroline Wozniacki vs Denisa Allertova
(8) Ekaterina Makarova vs Magdalena Rybarikova
(10) Angelique Kerber vs Anastasia Pavlyuchenkova
Ying-Ying Duan vs Tatjana Maria