Fury is the mandatory challenger to face Klitschko and, though the fight is not set in stone yet, Wilder feels that the undefeated British fighter has what it takes to upset the champion.
Wilder, who fights Eric Molina in Alabama next month, is being linked as an opponent for both Klitschko and Fury.
Fury is physically large and taller than Klitschko and is undefeated in 24 fights with 18 knockouts.
In a chat with BoxingScene.com, Wilder feels that if Fury boxes smartly the champion will struggle.
"I think he's got a hell of a chance to win, but I think it's going to be up to Tyson Fury on how he dedicates himself to his boxing. It depends on how seriously he takes this fight.
"You've seen many times where Tyson was hit and went down from smaller guys. If Klitschko hit's him, will he be able to get up like he has from the smaller guys?" Wilder told BoxingScene.com.
"He will have to rough Wladimir up. With the Chisora fight he wasn't worried. You can tell in the first couple of rounds what type of fighter he would be. He was like a kid in a playground.
"He was able to do anything he wanted. With Klitschko, I agree that he has to come out there and rough him up, but he has to be smart. That's the thing with taller fighters – you make one mistake and you can get punished," he added.