England ended on 464 all out in their first innings ??? Joe Root left stranded on 182 not out after a bizarre run-out of James Anderson for the final wicket.
It was one of two run-outs in the morning ??? the other Chris Jordan (16) ??? as England???s lower-order were sloppy, adding just 27 runs to the overnight total, compared to Root???s 64.
Jos Buttler (13) was the first wicket to fall, stumped when skipping down the pitch to Devendra Bishoo a ball after having struck the legspinner down the ground for four attempting the same shot.
Jordan played nicely ??? crunching a couple of fours away in impressive fashion ??? after benefitting from a slice of luck with an inside edge onto the stumps from his third ball not dislodging the bails.
The bails were dislodged, by Ramdin, when Jordan was run out for 16 later in the session ??? although it took third umpire Billy Bowden over four minutes to make the decision with Jordan desperately close to making his ground.
Stuart Broad came and went within an over ?????as he is becoming accustomed to during a terrible run of recent form ??? gloving Bishoo to Smith when attempting the sweep.
He called for the review ??? as he is also accustomed to doing ??? thinking it hit his arm guard rather than glove, but replays confirmed it brushed both.
Root had brought up his 150 two balls prior to Broad???s dismissal, and with just Anderson???s wicket left, the Yorkshire batsman starting taking a few more risks in search of a second Test double-hundred.
He hit two huge sixes off Bishoo, the first a lovely lofted drive straight down the ground and then an emphatic slog-sweep over midwicket a couple of overs later.
But sadly a brain-freeze from Anderson in the next over brought the innings to an end. Root called for a risky second run looking to keep the strike and despite a wayward throw from the fielder, Jason Holder still had plenty of time to take the bails off with Anderson strolling home and not grounding his bat.
It meant England had a healthy lead of 165 and a chance to bowl at the West Indies before lunch.
It proved to be a blessing as Anderson more than made up for his earlier error with the wicket of Smith for two, the opener dragging on to his stumps when indecisively playing at an away-swinger.
Moeen Ali almost added another in the final over before lunch as a thick outside edge from Darren Bravo just evaded second slip.