The Belgium defender left the field on a stretcher at Stoke last week with what the Saints boss said was a “dislocated shoulder”, yet he is in line to feature against Spurs on Saturday.
Victor Wanyama (suspension) and Filip Djuricic (ankle) remain absent, as do Fraser Forster, Jay Rodriguez and Emmanuel Mayuka. Sam Gallagher will not feature, despite scoring the winner in Monday’s Under-21 Premier League Cup final.
Hugo Lloris’ knee injury will be assessed ahead of Tottenham’s trip to Southampton on Saturday.
The France goalkeeper has been out for three matches since sustaining the injury against Leicester but could return for Mauricio Pochettino’s first game back at former club Saints.
Right-back Kyle Walker is out for four more weeks after suffering a foot injury against Burnley last month and could miss the rest of the season.