The world No 1 is targeting the elusive French Open title and began his warm-up for Roland Garros in the second round, completing a 6-1 6-4 victory in his home tournament.
In just his first service game, the Spaniard was drawn into an early battle to avoid being broken, and soon slipped behind after an ugly, mishit backhand.
Djokovic was feasting upon a string of half-hearted returns and a towering smash opened up a 4-0 advantage.
In a rare show of resistance, Ramos-Vinolas produced a perfectly weighted drop shot while breaking back, but only briefly stemmed the Serb???s progress as he seized the first set.
The Barcelona man eventually forced Djokovic out of cruise control in the second, prompting applause from the top seed with a precise backhand pass.
But he could not put a dent in Djokovic???s serve and following a lengthy time out, Ramos-Vinolas conceded a break with a wild forehand. ??
With victory in his grasp, the 2013 champion calmly served out ??to set up a clash with the winner of Bernard Tomic’s clash against??Andreas Haider-Maurer.
Djokovic felt he maintained his normal high standards after extending his??winning streak to 13 matches following back-to-back titles at Indian Wells and Miami
“I’m really pleased with my performance for my first match on clay against an experienced player on this surface,” he said. “There was a good intensity.”