Spain beat Italy 3-0 at the Santiago Bernabeu on Saturday in their World Cup Qualifying match to grab a stranglehold on Group G.
Isco grabbed two goals during a scintillating display from Spain, the Madrid star beating Gianluigi Buffon with a free-kick before adding a second with a shot from outside the penalty area.
Chelsea striker Alvaro Morata added a third from Sergio Ramos’ cross at the far post after coming on a substitute.
It was Italy’s first defeat in a qualifier since 2006.
Spain lead the group with 19 points while Italy have 16.
Only the winner from each group qualifies directly for Russia, with the eight best second-placed teams entering play-offs.