Argentina have been forced to make a late change to their side that will face Australia after Jeronimo de la Fuente failed a fitness test.
Santiago Gonzalez Iglesias will now start in their number 12 jersey with De la Fuente ruled out with a leg injury sustained during training.
Juan Martin Hernandez is called onto the bench as Argentina look to end their Rugby Championship campaign on a high note, something back-row Pablo Matera is desperate to do at Estadio Malvinas Argentinas in Mendoza.
"We are failing to carry out the game plan," he told AAP.
"The system is not failing, it is us players who are failing."
He added: "If we beat Australia, we can finish the championship by beating a top team.
"To beat Italy in November will not give us anything."
Argentina (revised): 15 Joaquin Tuculet, 14 Matias Moroni, 13 Matias Orlando, 12 Santiago Gonzalez Iglesias, 11 Emiliano Boffelli, 10 Nicolas Sanchez, 9 Martin Landajo, 8 Tomas Lezana, 7 Javier Ortega Desio, 6 Pablo Matera, 5 Matias Alemanno, 4 Marcos Kremer, 3 Nahuel Tetaz Chaparro, 2 Agustin Creevy (c), 1 Lucas Noguera Paz
Replacements: 16 Julian Montoya, 17 Santiago Garcia Botta, 18 Enrique Pieretto, 19 Banjamin Macome, 20 Leonardo Senatore, 21 Gonzalo Bertranou, 22 Juan Martin Hernandez, 23 Santiago Cordero
Date: Saturday, October 7
Venue: Estadio Malvinas Argentinas, Mendoza
Kick-off: 19:40 local (22:40 GMT)
Referee: Mathieu Raynal (France)
Assistant referees: Jaco Peyper (South Africa), Marius van der Westhuizen (South Africa)
TMO: Marius Jonker (South Africa)