Stephen Moore has been named as starting hooker in his final match as the Wallabies take on Scotland at Murrayfield on Saturday.
Moore has been joined in the 23 by Taniela Tupou, who has been thrown straight into the squad just two days after becoming eligible for Test duty.
Tupou joined the squad last week in London, after the NRC season wrapped, and has done enough to impress coach Michael Cheika in his training sessions.
Ben McCalman will start at six in place of injured Ned Hanigan, with Lukhan Tui cleared of a hamstring injury to play off the bench, and Matt Philip dropping out.
Tetera Faulkner replaces Allan Alaalatoa in the replacement loosehead spot.
Henry Speight comes onto the pine, in a five-three combination.
Australia: 15 Kurtley Beale, 14 Marika Koroibete, 13 Tevita Kuridrani, 12 Samu Kerevi, 11 Reece Hodge, 10 Bernard Foley, 9 Will Genia, 8 Sean McMahon, 7 Michael Hooper (c), 6 Ben McCalman, 5 Blake Enever, 4 Rob Simmons, 3 Sekope Kepu, 2 Stephen Moore, 1 Scott Sio
Replacements: 16 Tatafu Polota-Nau, 17 Tetera Faulkner, 18 Taniela Tupou, 19 Lukhan Tui, 20 Lopeti Timani, 21 Nick Phipps, 22 Karmichael Hunt, 23 Henry Speight
Date: Saturday, November 18
Kick-Off: 14:30 GMT
Referee: Pascal Gaüzère (France)
Assistant referees: John Lacey (Ireland), David Wilkinson (Ireland)
TMO: Graham Hughes (England)