Matic sits out the first of his two-match suspension after his dismissal for his reaction to a tackle by Burnley’s Ashley Barnes last weekend, while John Obi Mikel (knee) remains out, so Ramires is likely to start in midfield.
Boss Jose Mourinho has decisions to make in goal, with Thibaut Courtois likely to be selected ahead of Petr Cech, and in central defence, with Kurt Zouma and Gary Cahill competing to start alongside John Terry.
Tottenham have no fresh injury worries.
Mauricio Pochettino made seven alterations for Thursday’s Europa League tie at Fiorentina, starting the likes of Harry Kane, Andros Townsend and Kyle Walker from the bench with the Wembley finale in mind.
The Spurs head coach has to choose whether to start Hugo Lloris and Michel Vorm in goal, while captain Younes Kaboul, Emmanuel Adebayor and Etienne Capoue will be sweating on their place in the squad after being left in London for the last-32 tie.